Change of inhibitory input to the spinal neurons in spina bifida
Project/Area Number |
15K20005
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
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Research Institution | Ehime University |
Principal Investigator |
Khan MD.Sakirul 愛媛大学, 医学系研究科, 助教(特定教員) (70746867)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | spina bifida / chick / inhibitory input / GABA / 二分脊椎 / ヒヨコ / 運動異常 / 神経障害 / 鶏胚 / 脊髄 / 運動神経 |
Outline of Final Research Achievements |
We investigated the neuropathological mechanisms of progression of SBA-like motor dysfunctions in a neural tube surgery-induced chicken model of SBA at different pathogenesis points ranging from embryonic to posthatch ages. We found that chicks with SBA-like features lose voluntary leg movements and subsequently exhibit lower-limb paralysis within the first 2 weeks after hatching, coinciding with the synaptic change-induced disruption of spinal motor networks at the site of the SBA lesion in the lumbosacral region. Such synaptic changes reduced the ratio of inhibitory-to-excitatory inputs to motor neurons and were associated with a drastic loss of γ-aminobutyric acid (GABA)ergic inputs and upregulation of the cholinergic activities of motor neurons. Furthermore, most of the neurons in ventral horns, which appeared to be suffering from excitotoxicity during the early postnatal days, underwent apoptosis. (Disease Models & Mechanisms 10, 1421-1432, 2017)
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Immune therapy for hepatitis B.2016
Author(s)
Akbar SMF, Al-Mahtab M, Khan MSI, Raihan R, Shrestha A.
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Journal Title
Annals of Translational Medicine.
Volume: 4
Issue: 18
Pages: 335-335
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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