Analysis of micro RNA related to osteosarcoma metastasis
| Project/Area Number |
15K20009
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Tome Yasunori 琉球大学, 医学(系)研究科(研究院), 准教授 (20547369)
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| Research Collaborator |
Kiyuna Tasuku 琉球大学, 医学研究科, 大学院生
Oshiro Hiromichi 琉球大学, 医学研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | miRNA / 骨肉腫 / 肺転移 |
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| Outline of Final Research Achievements |
Total RNAs including micro RNAs were extracted from parental human osteosarcoma 143B cells and highly metastatic 143B-LM4 cells. mir-143 and mir-145 were higher expressed in 143B-LM4 cells compared to 143B cells. Moreover, DNA microarray analysis was performed using extracted RNAs. TANGLM and LASP1, which are related to mir-143 and mir-145, were highly expressed. Further analysis would be performed with 143B cells and 143B-LM4 cells regarding TANGLM and LASP1.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Labeling the stroma of a patient-derived orthotopic xenograft (PDOX) mouse model of undifferentiated pleomorphic soft-tissue sarcoma with red fluorescent for rapid non-invasive imaging for drug screening.2017
Author(s)
Tasuku Kiyuna, Takashi Murakami, Yasunori Tome, Kentaro Igarashi, Kei Kawaguchi, Tara Russel, Mark Eckardt, Joseph Crompton, Arun Singh, Nicholas Bernthal, Susan Bukata, Noah Federman, Fuminori Kanaya, Fritz C. Eliber, Robert M. Hoffman.
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Journal Title
J Cell Biochem
Volume: 118(10)
Issue: 2
Pages: 361-365
DOI
Related Report
Peer Reviewed
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