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Establishment of clinically applicable conditions for prevention of steroid induced osteonecrosis using quantitative evaluation by higher-resolution MRI

Research Project

Project/Area Number 15K20010
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Ishida Masashi  京都府立医科大学, 医学(系)研究科(研究院), 講師 (40725660)

Research Collaborator IKOMA Kazuya  京都府立医科大学, 医学(系)研究科(研究員), 講師 (50516044)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords特発性大腿骨頭壊死症 / MRI / 電気刺激 / ステロイド / MRI / 特発性大腿骨頭壊死 / DCE-MRI / 電磁場刺激
Outline of Final Research Achievements

This study aimed to evaluate femoral perfusion using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in a steroid-induced osteonecrosis (ON) model. Seven rabbits underwent electrical stimulation (ES) (ES group), and seven rabbits did not (control group). DCE-MRI was performed before steroid and 1, 5, 10, and 14 days after steroid. The enhancement ratio, initial slope, and area under the curve were analyzed.These parameters were evaluated after steroid administration in each group and between the two groups, and the ratios of ON in both groups were compared. In the control group, the minimum values of all parameters decreased significantly after steroid administration (P < 0.05), but in theES group, the parameters did not decrease. In the control group, ON was detected in three of five rabbits. In the ES group, ON was not detected. These results suggest that increased femoral blood flow elicited by ES may be related to ON prevention after steroid administration.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Evaluation of femoral perfusion using dynamic contrast-enhanced MRI after simultaneous initiation of electrical stimulation and steroid treatment in an osteonecrosis model2018

    • Author(s)
      Yamamoto Hiroki、Ueshima Keiichiro、Saito Masazumi、Ikoma Kazuya、Ishida Masashi、Goto Tsuyoshi、Hayashi Shigeki、Ikegami Akira、Fujioka Mikihiro、Mazda Osam、Kubo Toshikazu
    • Journal Title

      Electromagnetic Biology and Medicine

      Volume: Epub ahead of print Issue: 2 Pages: 1-11

    • DOI

      10.1080/15368378.2018.1466310

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Femoral perfusion after pulsed electromagnetic field stimulation in a steroid-induced osteonecrosis model2015

    • Author(s)
      Ikegami A et al.
    • Journal Title

      Bioelectromagnetics

      Volume: 未定 Issue: 5 Pages: 349-357

    • DOI

      10.1002/bem.21910

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] "Evaluation of Femoral Perfusion using DCE-MRI after Simultaneous Initiation of Electrical Stimulation and Steroid Treatment in an Osteonecrosis Model "2017

    • Author(s)
      Yamamoto Hiroki
    • Organizer
      62th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      SanDiego, California, USA
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation of Femoral Perfusion using DCE-MRI after Simultaneous Initiation of Electrical Stimulation and Steroid in an Osteonecrosis Model2017

    • Author(s)
      Yamamoto Hiroki、Ueshima Keiichiro、Ikoma Kazuya、Ishida Masashi、Goto Tsuyoshi、Saito Masazumi、Hayashi Shigeki、Ikegami Akira、Fujioka Mikihiro、Kubo Toshikazu
    • Organizer
      25th Annual Meeting of the European Orthopaedic Research Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ステロイド投与と同日に電気刺激を開始した家兎ステロイド性骨壊死モデルにおける大腿骨内の血流評価2017

    • Author(s)
      山本浩基
    • Organizer
      生体電気物理刺激学会
    • Place of Presentation
      京都
    • Related Report
      2016 Research-status Report
  • [Presentation] ステロイド投与と同日に開始した電気刺激による家兎骨壊死モデルの骨内血流評価2016

    • Author(s)
      山本浩基
    • Organizer
      第43回日本股関節学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
  • [Presentation] ステロイド投与同日に電気刺激を開始した家兎ステロイド性骨壊死モデルにおける大腿骨内の血流評価2016

    • Author(s)
      山本浩基
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Vit.E plus pitavastatin treatment restrained the early blood-flow fall after the steroid administration to the steroid- induced osteonecrosis model2016

    • Author(s)
      池上 徹,上島圭一郎,生駒和也,石田雅史,齊藤正純,林 成樹,藤岡幹浩,松田 修,久保俊一
    • Organizer
      62th Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      Disney's Coronado Springs Resort, Orlando, Florida,USA
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ステロイド投与と同時に電気刺激を開始した家兎ステロイド性骨壊死モデルにおける大腿骨内の血流評価2015

    • Author(s)
      山本浩基,上島圭一郎,石田雅史,齊藤正純,生駒和也,林 成樹,池上 徹,藤岡幹浩,久保俊一
    • Organizer
      日本医療研究開発機構(AMED)研究費 難治性疾患実用化研究事業 平成27年度 第2回班会議
    • Place of Presentation
      大阪府, 吹田市, 大阪大学銀杏会館
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
  • [Presentation] ステロイド性骨壊死モデルに対するスタチン投与後の大腿骨血流評価2015

    • Author(s)
      池上 徹,上島圭一郎,石田雅史,齊藤正純,藤岡幹浩,林 成樹,栗林正明,久保俊一
    • Organizer
      第42回日本股関節学会学術集会
    • Place of Presentation
      大阪府, 大阪市, グランフロント大阪
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] スタチン投与を行った家兎ステロイド性骨壊死モデルの大腿骨内血行動態の評価2015

    • Author(s)
      池上 徹,齊藤正純,上島圭一郎,生駒和也,石田雅史,林 成樹,藤岡幹浩,松田 修,久保俊一
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山県, 富山市, 富山国際会議場
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] ビタミンEとピタバスタチン併用投与後のステロイド性骨壊死モデルにおける大腿骨内の血流評価2015

    • Author(s)
      池上 徹,上島圭一郎,石田雅史,齊藤正純,生駒和也,林 成樹,山本浩基,藤岡幹浩,久保俊一
    • Organizer
      日本医療研究開発機構(AMED)研究費 難治性疾患実用化研究事業 平成27年度 第1回班会議
    • Place of Presentation
      大阪府, 大阪市, グランフロント大阪
    • Year and Date
      2015-08-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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