| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In the current study, we elucidated the patho-mechanism of low back pain and joint pain in elderly patients or animal models with osteoporosis or sarcopenia or osteoarthritis. Several molecules including inflammatory cytokines, various growth factors and pain-related molecules were observed in osteoporotic bone marrow, high aged muscle tissue and synovial tissue in osteoarthritis joints. In addition, multiple nerve fibers with pain-related molecules in osteoporotic vertebral body were observed. These findings might be related with pain in elderly patients.
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