The Pathomechanism of Pain in Elderly Patients with Musculoskeletal Ambulation Disability Symptom Complex

• Project/Area Number: 15K20016
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kitasato University
• Principal Investigator: Miyagi Masayuki 北里大学, 医学部, 講師 (90627556)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 慢性疼痛 / 骨粗鬆症 / サルコペニア / 変形性関節症 / 腰痛 / 炎症性サイトカイン / レプチン / 神経成長因子 / 骨粗鬆症性疼痛

Outline of Final Research Achievements

In the current study, we elucidated the patho-mechanism of low back pain and joint pain in elderly patients or animal models with osteoporosis or sarcopenia or osteoarthritis. Several molecules including inflammatory cytokines, various growth factors and pain-related molecules were observed in osteoporotic bone marrow, high aged muscle tissue and synovial tissue in osteoarthritis joints. In addition, multiple nerve fibers with pain-related molecules in osteoporotic vertebral body were observed. These findings might be related with pain in elderly patients.

Research Products

• [Journal Article] Adrenomedullin Regulates IL-1β Gene Expression in F4/80+ Macrophages during Synovial Inflammation. (2017)
  • Author(s): Takano S, Uchida K, Miyagi M, Inoue G, Aikawa J, Iwabuchi K, Takaso M.
  • Journal Title: J Immunol Res. Volume: - Pages: 1-10
  • DOI: 10.1155/2017/9832430
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activation of calcitonin gene-related peptide signaling through the prostaglandin E2-EP1/EP2/EP4 receptor pathway in synovium of knee osteoarthritis patients. (2016)
  • Author(s): Atsushi Minatani, Kentaro Uchida, Gen Inoue, Shotaro Takano, Jun Aikawa, Masayuki Miyagi, Hisako Fujimaki, Dai Iwase, Kenji Onuma, Toshihide Matsumoto, Masashi Takaso
  • Journal Title: Journal of orthopaedic surgery and reserch Volume: - Issue: 1 Pages: 117-117
  • DOI: 10.1186/s13018-016-0460-4
  • Peer Reviewed / Open Access
• [Presentation] 重症骨粗鬆症に対する薬物治療 (2017)
  • Author(s): 宮城正行
  • Organizer: 相模原市内科医会学術講演会
  • Place of Presentation: 小田急ホテルセンチュリー相模大野（神奈川県相模原市）
  • Invited
• [Presentation] 骨粗鬆症と痛み (2016)
  • Author(s): 宮城正行
  • Organizer: 第4回伊豆ペインフォーラム
  • Place of Presentation: 青山やまと（静岡県伊東市）
  • Invited
• [Presentation] 骨粗鬆症診療最新の話題 (2016)
  • Author(s): 宮城正行
  • Organizer: 第6回相模原骨粗鬆症Update研究会
  • Place of Presentation: ラポール千寿閣（神奈川県相模原市）
  • Invited