| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
As the pathology of knee osteoarthritis (knee OA) is diverse, we focused on synovitis and osteophyte formation in the knee OA. The aim of this study was to investigate the role of perlecan expressed in synovium in the early stage of synovitis and osteophyte formation in knee OA. The absence of synovial perlecan suppressed osteophyte formation and enhanced synovitis, although there was no difference in articular cartilage degeneration in the early stage of knee OA. These results suggest that that perlecan plays an important role for not only the cartilage differentiation from synovial mesenchymal cells but also for the synovial inflammation, which may be involved in osteophyte formation.
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