Genetic association of Dyslipidemia in patients with rheumatoid arthritis

• Project/Area Number: 15K20020
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Yoshida Shinji 東京女子医科大学, 医学部, 助教 (80464882)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 関節リウマチ / 脂質異常症 / 遺伝子 / 候補遺伝子解析

Outline of Final Research Achievements

Susceptibility genes to rheumatoid arthritis (RA) and genes modulating lipid profiles validated in the Japanese general population were genotyped. We investigated genetic association between serum low-density lipoprotein cholesterol (LDL-C) levels in Japanese patients with RA and each single nucleotide polymorphism by multivariate linear regression analyses. The results revealed that the minor allele of rs3093024 (CCR6), rs1160542 (AFF3) and rs10465436 (P2RY10) in susceptibility genes to RA was associated with lower serum LDL-C levels. However, those associations were not significant after Bonferroni correction for multiple comparisons. Patients with minor alleles of rs7412 (APOE) in genes modulating lipid profiles had significantly higher serum LDL-C levels. An APOE polymorphism is a genetic risk factor for higher serum LDL-C levels in Japanese patients with RA.

Research Products

• [Presentation] A TRAF1 gene polymorphism is a genetic risk for radiographic progression of joint destruction in anti-citrullinated peptide antibody-negative rheumatoid arthritis (2016)
  • Author(s): Shinji Yoshida, Katsunori Ikari, Koichiro Yano, Morio Matsumoto, Masaya Nakamura, Atsuo Taniguchi, Hisashi Yamanaka, Shigeki Momohara
  • Organizer: 18th Asia Pacific League of Associations for Rheumatology Congress
  • Place of Presentation: Shanghai, China
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] Impact of disease susceptibility genes on serum low-density lipoprotein cholesterol levels in Japanese patients with rheumatoid arthritis (2015)
  • Author(s): Shinji Yoshida, Katsunori Ikari, Morio Matsumoto, Masaya Nakamura, Atsuo Taniguchi, Hisashi Yamanaka, Shigeki Momohara
  • Organizer: 17th Asia Pacific League of Associations for Rheumatology Congress
  • Place of Presentation: Chennai, India
  • Year and Date: 2015-09-06
  • Int'l Joint Research
• [Presentation] Association of serum low-density lipoprotein cholesterol levels with disease activity and genetic factors in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study (2015)
  • Author(s): Shinji Yoshida, Katsunori Ikari, Atsuo Taniguchi, Hisashi Yamanaka, Shigeki Momohara
  • Organizer: 第59回日本リウマチ学会総会・学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-04-23