Inhibition of Mitochondrial Fission Protein Reduced Mechanical Allodynia and Suppressed Spinal Mitochondrial Superoxide
| Project/Area Number |
15K20026
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
IIDA Takafumi 旭川医科大学, 医学部, 助教 (40468442)
KANDA Megumi 旭川医科大学, 医学部, 助教 (50516820)
Hao Shuanglin University of Miami, Research Assoc, Professor
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 神経障害性疼痛 / ミトコンドリア / 遺伝子治療 / fission / Drp-1 |
|---|
| Outline of Final Research Achievements |
In summary, mitochondrial division is critical for the maintenance
of the structure and function of neurons. Although the mechanisms underlying HIV-related neuropathic pain are poorly understood, the current results provide important insights into the pathogenesis of mitochondrial division in the HIV-related neuropathic pain state.
|
Report
(3 results)
Research Products
(3 results)
