Role of histamine nervous system in inhaled anesthesia.

• Project/Area Number: 15K20028
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Tohoku Medical and Pharmaceutical University (2016); Tohoku University (2015)
• Principal Investigator: NAKAMURA Tadaho 東北医科薬科大学, 医学部, 准教授 (80734318)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 吸入麻酔薬 / 中枢神経系薬理 / ヒスタミン神経系 / 中枢神経薬理

Outline of Final Research Achievements

In present study, we focused on the relation between inhaled anesthetics and histamine nervous system. We found that histamine H1 receptor was involved in loss of consciousness induced by inhaled anesthetics and histamine release from histamine neurons in posterior hypothalamus was facilitated by inhaled anesthetics.

Research Products

• [Journal Article] JNJ10181457, a Histamine H3 Receptor Inverse Agonist, Regulates in vivo Microglial Functions and Improves Depression-like Behaviours in Mice (2017)
  • Author(s): Tomomitsu Iida, Takeo Yoshikawa, Aniko Karpati, Takuro Matsuzawa, Haruna Kitano, Asuka Mogi, Ryuichi Harada, Fumito Naganuma, Tadaho Nakamura, Kazuhiko Yanai
  • Journal Title: Biochemical and Biophysical Research Communications (BBRC) Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Electroencephalogram of H1KO mice under isoflurane aneasthesia (2016)
  • Author(s): Nakamura T, Yoshikawa T, Naganuma F, Mohsen A, Iida T, Karpati A, Tamii T, Okamura N, Yanai K.
  • Journal Title: Inflammation Research Volume: 55
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Histamine H3 receptor in primary mouse microglia inhibits chemotaxis, phagocytosis, and cytokine secretion. (2015)
  • Author(s): Iida T, Yoshikawa T, Matsuzawa T, Naganuma F, Nakamura T, Miura Y, Mohsen AS, Harada R, Iwata R, Yanai K.
  • Journal Title: Glia Volume: - Issue: 7 Pages: 1213-1225
  • DOI: 10.1002/glia.22812
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] G-cell hyperplasia of the stomach induces ECL-cell proliferation in the pyloric glands in a paracrinal manner (2015)
  • Author(s): Kasajima, A. Fujishima, F. Morikawa, T. Kawasaki, S. Konosu-Fukaya, S. Shibahara, Y. Nakamura, T. Yoshikawa, T. Iijima, K. Koike, T. Watanabe, M. Shibata, C. Sasano, H.
  • Journal Title: Pathology International Volume: 65 Issue: 5 Pages: 259-63
  • DOI: 10.1111/pin.12276
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Interactions between histaminergic neuronal system and isoflurane anesthesia in mice (2017)
  • Author(s): Toru Tamii, Tadaho Nakamura, Takeo Yoshikawa, Osamu Kobayashi, Masanori Yamauchi, Kazuiko Yanai
  • Organizer: 日本麻酔科学会第63回学術集会
  • Place of Presentation: マリンメッセ福岡（福岡県福岡市）
  • Year and Date: 2017-05-27
• [Presentation] The effect of H3 receptor antagonist on neuropathic pain (2017)
  • Author(s): Tadaho Nakamura, Takuro Matsuzawa, Maria Mogilevskaya, Asuka Mogi, Takeo Yoshikawa, Fumito Naganuma, Nobuyuki Okamura and Kazuhiko Yanai
  • Organizer: Histamine 2017
  • Place of Presentation: Amsterdam (the Netherlands)
  • Year and Date: 2017-05-11
  • Int'l Joint Research
• [Presentation] Role of histamine receptors in desflurane anesthesia (2017)
  • Author(s): Toru Tamii, Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Tomomitsu Iida, Aniko Karpati, Takuro Matsuzawa, Nobuyuki Okamura and Kazuhiko Yanai
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎パブリックホール（長崎県長崎市）
  • Year and Date: 2017-03-15
• [Presentation] Role of histamine neurons in isoflurane anesthesia. (2016)
  • Author(s): Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Tomomitsu Iida, Aniko Karpati, Toru Tamii, Nobuyuki Okamura, Kazuiko Yanai
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
  • Int'l Joint Research
• [Presentation] Electroencephalogram of H1KO mice under isoflurane anesthesia (2016)
  • Author(s): Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Tomomitsu Iida, Aniko Karpati, Toru Tamii, Nobuyuki Okamura, Kazuiko Yanai
  • Organizer: European Histamine Research Society 45th Annual Meeting
  • Place of Presentation: Florence (Italy)
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Interactions between histaminergic neuronal system and isoflurane anesthesia in mice (2016)
  • Author(s): Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Tomomitsu Iida, Yamato Miura, Aniko Karpati, Kazuiko Yanai
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-09
• [Presentation] ヒスタミン神経系におけるイソフルランの作用 (2015)
  • Author(s): 中村正帆、吉川雄朗、長沼史登、三浦大和、飯田智光、松澤拓郎、堀米愛、Aniko Karpati、谷内一彦
  • Organizer: 第19回日本ヒスタミン学会
  • Place of Presentation: 東北大学片平さくらホール（宮城県仙台市）
  • Year and Date: 2015-11-13
• [Presentation] Role of histaminergic neuronal system in isoflurane anesthesia (2015)
  • Author(s): Nakamura T, Yoshikawa T, Naganuma F, Kobayashi O, Kaneko M, Yamauchi M, Yanai K
  • Organizer: ANESTHESIOLOGY 2015
  • Place of Presentation: San Diego, USA
  • Year and Date: 2015-10-24
  • Int'l Joint Research
• [Presentation] イソフルランの麻酔作用におけるヒスタミン神経系の役割 (2015)
  • Author(s): 中村正帆、吉川雄朗、長沼史登、三浦大和、飯田智光、松澤拓郎、堀米愛、Aniko Karpati、谷内一彦
  • Organizer: 第66回日本薬理学会北部会
  • Place of Presentation: 富山国際会議場（富山県富山市）
  • Year and Date: 2015-09-18
• [Presentation] H1-KNOCKED OUT MOUSE HAS HIGH SENSITIVITY TO ISOFLURANE ANESTHESIA. (2015)
  • Author(s): T. Nakamura, T. Yoshikawa, F. Naganuma, T. Iida, Y. Miura and K. Yanai
  • Organizer: European Histamine Research Society 44th Annual Meeting
  • Place of Presentation: Malaga, Spain
  • Year and Date: 2015-05-06
  • Int'l Joint Research
• [Book] “Histamine H1 receptor occupancy in human brain.” In: Histamine Receptors: Preclinical and Clinical Aspects (2016)
  • Author(s): Yanai K, Hiraoka K, Karp&ati A, Naganuma F, Okamura N, Tashiro M, Nakamura T, and Yoshikawa T.
  • Total Pages: 380
  • Publisher: S Springer