| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
· Purpose: In recent years, neurotoxicity due to anesthetic has been pointed out. We investigated the molecular mechanism of neurotoxicity by inhalation anesthetics using gene mutant mice with impaired endoplasmic reticulum function.
· Results: Exposure of mutant BiP (endoplasmic reticulum chaperone molecule) knock-in mice and wild type mice to the inhalation anesthetic sevoflurane during embryonic development tends to induce more neuronal cell death in mutant BiP knockin mice in the short term It was done. Suggesting the possibility that cognitive decline due to aging may be accelerated in the long term.
· Discussion: It is suggested that inhalation anesthetics inhibit endoplasmic reticulum function, which may lead to neurological disorders both short-term and long-term. In individuals sensitive to neurotoxicity, it is necessary to consider the amount of anesthetic to be used.
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