Modification of general anesthetic actions in diabetes model rats and clinical implications for anesthesia managements in diabetes patients

Research Project

Project/Area Number	15K20033
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	University of Toyama
Principal Investigator	Honda Yasuko 富山大学, 附属病院, 助教 (50724572)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	糖尿病 / GKラット / 海馬 / シナプス伝達 / 全身麻酔薬 / チオペンタール / GABA / 興奮性シナプス伝達 / 抑制性シナプス伝達 / 揮発性麻酔薬 / 静脈麻酔薬 / 疾患モデル動物 / 脳スライス標本
Outline of Final Research Achievements	It has been reported that diabetes impairs hippocampal functions in the central nervous system. In order to demonstrate modification of general anesthetic actions in diabetes, we have studied effects of thiopental on hippocampal synaptic transmission in diabetes model rats (GK rats). The results indicated that diabetes attenuates the inhibitory neurotransmitter (GABA) due to the impairment of GABA recruitment at presynaptic terminals, suggesting that diabetes deteriorates postanesthetic cognitive dysfunction or emergence agitation in clinical anesthesia.