Involvement of CGRP and adrenomedullin in animal models of neuropathic pain

Research Project

Project/Area Number	15K20039
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Shinshu University
Principal Investigator	Ishida Kumiko 信州大学, 医学部, 助教(特定雇用) (80467191)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	神経因性疼痛 / CGRP / CGRPファミリー / AM
Outline of Final Research Achievements	We studied the involvement of αCGRP in neuropathic pain model by using αCGRP knockout mice and wild type mice. Our study suggested that αCGRP was not involved in spontaneous pain, thermal hyperalgesia and mechanical hyperalgesia in partial sciatic nerve ligation model.