| Project/Area Number |
15K20043
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | NMDA受容体 / 亜酸化窒素 / キセノン / ケタミン / オピオイド受容体 / 吸入麻酔薬 / 静脈麻酔薬 / 鎮痛作用 / 鎮静作用 |
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| Outline of Final Research Achievements |
It has been shown that the nociceptin receptor is involved in the analgesic action of nitrous oxide, and that the analgesic action of nitrous oxide in the mu-opioid receptor knockout mice is not significantly different from that in the wild-type mice. In this study, we have analyzed the analgesic action of nitrous oxide in the kappa-opioid receptor knockout mice. It was demonstrated that the analgesic action of nitrous oxide was almost completely lost in the kappa-opioid receptor knockout mice. In contrast, the sedative action of nitrous oxide, which was estimated by loss of righting reflex, was not significantly different between kappa-opioid receptor knockout mice and wild-type mice. These results suggest that the analgesic action and the sedative action of nitrous oxide are mediated by different mechanisms.
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