Regulation of the circadian clocks by phototherapy in the systemic inflammatory response syndrome

• Project/Area Number: 15K20048
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Oita University
• Principal Investigator: Oyama Yoshimasa 大分大学, 医学部, 助教 (40468012)
• Research Collaborator: MATSUMOTO Sigekiyo ; HAYASHIDA Tatsunori
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 光治療 / 敗血症 / 光療法 / 行動活性

Outline of Final Research Achievements

Phototherapy has been used to control the inflammation or treat circadian rhythm disorders. However, the mechanism of phototherapy is still unclear. We investigated the anti-inflammatory effect of phototherapy on the systemic inflammatory response syndrome using the analysis of behavior rhythm and measuring cytokines production. While phototherapy had no effect on behavior rhythm after the systemic inflammatory response syndrome, green or red LED exposure showed significant decreases of the inflammatory cytokines production, but inducing anti-inflammatory cytokine. Based on these data, specific wavelength of light might play an important role in anti-inflammatory activities.