Spinal cord ischemia-reperfusion injury: a microdialysis study in the spinal ventral horn
Project/Area Number |
15K20057
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Anesthesiology
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Research Institution | Osaka City University |
Principal Investigator |
SUEHIRO Koichi 大阪市立大学, 大学院医学研究科, 講師 (10735806)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 脊髄虚血 / プレコンディショニング / マイクロダイアライシス / 神経アミノ酸 |
Outline of Final Research Achievements |
The present study aimed to investigate the protective effect of remote ischemic preconditioning (RIPC) against spinal cord ischemia (SCI) and reveal its mechanism by measuring the glutamate concentration using an in vivo microdialysis in the ventral horn of the spinal cord. RIPC by limb-ischemia attenuated the increase of glutamate concentration in n the ventral horn and the decrease of motor evoked potential (MEP) amplitude due to SCI, and improved the post-SCI motor function and histopathologic changes in the spinal cord. Additionally, even with RIPC conditions, pre-administration of NMDA receptor antagonist (MK-801) led to increase the glutamate concentration and decrease MEP amplitude, and also worsened neurologic and histopathologic outcomes. Our study revealed that RIPC could show a protective effect against SCI both in early and late phases, and that the NMDA receptor played an important role for this preventive effect.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Impact of advanced monitoring variables on intraoperative clinical decision-making: an international survey2017
Author(s)
Alexandre Joosten, Olivier Desebbe, Koichi Suehiro, Mfonobong Essiet, Brenton Alexander, Cameron Ricks, Joseph Rinehart, David Faraoni, Maurizio Cecconi, Philippe Van der Linden, Maxime Cannesson.
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Journal Title
Journal of Clinical Monitoring and Computing
Volume: 31
Issue: 1
Pages: 205-212
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Impact of advanced monitoring variables on intraoperative clinical decision-making: an international survey.2016
Author(s)
Alexandre Joosten, Olivier Desebbe, Koichi Suehiro, Mfonobong Essiet, Brenton Alexander, Cameron Ricks, Joseph Rinehart, David Faraoni, Maurizio Cecconi, Philippe Van der Linden, Maxime Cannesson.
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Journal Title
Journal of Clinical Monitoring and Computing
Volume: 印刷中
Related Report
Peer Reviewed
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