| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, we examined the effect of volatile anesthetics to mouse striatal neurons using the whole-cell patch clamp technique. Sevoflurane, which is widely used in pediatric surgery, has drawn attention, because the preconditioning effects on hypoxia. It is recently reported that the effects of volatile anesthetics are partly mediated by ATP-sensitive potassium (KATP) channels. Our analyses showed that sevoflurane prolonged the time to depolarization of medium spiny neuron of mouse striatum under hypoxia during development from 7 to 35 days of age.
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