Relationship between D-amino acids and sleep disorder induced by general anesthetic

Research Project

Project/Area Number	15K20060
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Tokai University
Principal Investigator	WATANABE Mariko 東海大学, 医学部, 助教 (60609220)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	麻酔薬 / 概日リズム / 睡眠障害 / Dアラニン / Ｄアミノ酸酸化酵素欠損マウス / 全身麻酔薬 / Dアミノ酸 / Ｄアラニン / 脳内時計遺伝子 / ケタミン / NMDA受容体 / D-アラニン
Outline of Final Research Achievements	D-Alanine contents in serum or microdialyzate from thalamus of D-amino acid oxidase deficient mice is higher than one of wild type mice and regulated under circadian rhythm.