| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We investigated the effects of neurosteroid that have analgesic effect, pregnenolone sulfate and antidepressants, paroxetine that have been used for neuropathic pain on the function of P2X7 receptor using electrophysiological technique in order to contribute the development of selective P2X7 inhibitor as a novel analgesic for refractory chronic pain constituted by nociceptive and neuropathic pain. We found that these compounds inhibit the function of P2X7 receptor dose-dependently, and that the inhibitory effect is noncompetitive inhibition. These results would help to clarify the mechanisms underlying inhibition of P2X7 receptor function, and contribute the development of selective P2X7 receptor inhibitor.
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