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The regulation for laminin receptor expression of prostate cancer during EMT-MET process

Research Project

Project/Area Number 15K20067
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionHirosaki University

Principal Investigator

Tohru Yoneyama  弘前大学, 医学研究科, 助教 (50587649)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords神経周囲浸潤 / ラミニン受容体 / 上皮間葉移行 / EMT / ラミニンレセプター / 前立腺がん / 前立腺癌 / ラミニン / O型糖鎖
Outline of Final Research Achievements

Although tumor microenvironment of highly innervated prostate considered to be laminin-rich and up-regulation of metastasis promoting laminin-binding integrin α6β1 contributed to perineural invasion (PNI) and following metastasis of prostate cancer, many papers did not consider an anti-metastatic effect of laminin-binding glycan (LNBG) on α-dystroglycan in prostate cancer (PC). Here we identified that the SDF-1-CXCR4 axis and metastasis promoting integrin α6β1 upregulation occurred during EMT responsible for enhancement of migration capacity to perineural cells and perineural invasion capacity in metastatic PC cells. We also showed that translational repression of β4GAT1 by hsa-let-7i-5p miRNA was responsible for anti-metastatic LNBG depletion occurred during EMT process. These findings suggest that the SDF-1-CXCR4 axis and regulation of laminin receptor expression occurred during EMT especially, let-7i-5p regulated LNBG synthesis might be important for PNI and PC metastasis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 Other

All Int'l Joint Research (3 results) Presentation (5 results) Remarks (3 results)

  • [Int'l Joint Research] Sanford burnham prebys Med. Dis. Inst.(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Sanford Burnham Prebys Med. Dis. Inst.(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Sanford Burnham Prebys Med. Dis. Inst.(米国)

    • Related Report
      2015 Research-status Report
  • [Presentation] miRNAによって制御されるlaminin binding O-glycanの前立腺癌神経周囲浸潤、転移における役割2016

    • Author(s)
      米山 徹、飛澤悠葵、藤田尚紀、岩村大径、岡本 亜希子、山本勇人、盛 和行、畠山真吾、橋本安弘、古家琢也、福田 穰、大山 力
    • Organizer
      第104日本泌尿器科学会総会
    • Place of Presentation
      仙台国際会議場(宮城県・仙台市)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Role of anti-metastatic laminin-binding O-glycan on α-dystroglycan regulated by miR-X in prostate cancer.2016

    • Author(s)
      Tohru Yoneyama, Naoki Fujita, Hiromichi Iwamura, Akiko Okamoto, Hayato Yamamoto, Kazuyuki Mori, Shingo Hatakeyama, Yasuhiro Hashimoto, Takuya Koie, Yuki Tobisawa, Minoru Fukuda, Chikara Ohyama
    • Organizer
      European association of Urology annual meeting 2016
    • Place of Presentation
      ミュンヘン、ドイツ
    • Year and Date
      2016-03-11
    • Related Report
      2015 Research-status Report
  • [Presentation] miRNAによって制御されるラミニン結合O型糖鎖の前立腺癌神経周囲浸潤における役割2016

    • Author(s)
      米山 徹、藤田尚紀、岩村大径、岡本 亜希子、山本勇人、畠山真吾、古家琢也、飛澤悠葵、福田 穰、大山 力
    • Organizer
      第25回泌尿器科分子・細胞研究会
    • Place of Presentation
      ハイアットリージェンシー大阪/ATCコンベンションルーム大阪(大阪府)
    • Year and Date
      2016-02-26
    • Related Report
      2015 Research-status Report
  • [Presentation] The role of laminin-binding O-glycan regulated by miRNA for perineural invasion in prostate cancer2015

    • Author(s)
      Tohru Yoneyama, Naoki Fujita, Hiromichi Iwamura, Akiko Okamoto, Hayato Yamamoto, Shingo Hatakeyama, Takuya Koie, Yuki Tobisawa, Minoru Fukuda, Chikara Ohyama
    • Organizer
      第88回 日本生化学会
    • Place of Presentation
      神戸ポートピアホテル(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] The role of laminin-binding O-glycan on α-dystroglycan regulated by miRNA for perineural invasion in prostate cancer.2015

    • Author(s)
      米山 徹、藤田 尚紀、岩村 大径、岡本 亜希子、飛澤 悠葵、山本 勇人、畠山 真吾、古家 琢也、福田 穰、大山 力
    • Organizer
      第9回 東北糖鎖研究会
    • Place of Presentation
      東北薬科大学(仙台市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
  • [Remarks] 弘前大学大学院医学研究科泌尿器科学講座ホームページ

    • URL

      http://www.med.hirosaki-u.ac.jp/~uro/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 弘前大学大学院医学研究科 泌尿器科学講座ホームページ

    • URL

      http://www.med.hirosaki-u.ac.jp/~uro/

    • Related Report
      2016 Research-status Report
  • [Remarks] 弘前大学大学院医学研究科泌尿器科学講座

    • URL

      http://www.med.hirosaki-u.ac.jp/~uro/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-06-07  

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