Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Outline of Final Research Achievements |
Understanding the molecular mechanisms of the androgen-independent and metastatic signaling pathways underlying castration-resistant prostate cancer (CRPC) using current genomic approaches would help to improve therapies for and prevention of the disease. We sequenced small RNA libraries isolated from normal prostate tissue, prostate cancer (PCa) tissue and CRPC tissue. 267 miRNAs were significantly downregulated in CRPC compared with normal prostate specimen. miR-221/222 cluster was significantly downregulated in CRPC specimen. Gene expression data and in silico analysis demonstrated miR-221/222 regulated Ecm29 gene, which was highly expressed in CRPC specimen.
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