The analysis of the differences in antibody reaction against ABO antigen between red blood cells and renal endothelium

Research Project

Project/Area Number	15K20074
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	Niigata University
Principal Investigator	Tasaki Masayuki 新潟大学, 医歯学総合病院, 助教 (40571906)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	腎移植 / ABO血液型抗原 / 抗体 / ABO血液型 / 腎臓 / 赤血球 / ABO血液型不適合腎移植
Outline of Final Research Achievements	Despite the presence of antigens on the graft's vascular endothelium and the presence of antibodies in recipients' blood, clinical rejection does not always occur in ABO incompatible kidney transplantation. This phenomenon is called as accommodation. However, the mechanisms are undefined. We developed glycoconjugate microarray which is mimicked ABO blood group antigens expressed on human renal endothelium. In this study, we compared anti-A and anti-B antibodies reaction between red blood cells and renal endothelium. We found that antibodies production against donor blood group antigens of renal endothelium specifically inhibited after ABO incompatible kidney transplantation. This may be the mechanism of accommodation.

Report

(3 results)