Can detrusor overactivity induce detrusor underactivity independently of atherosclerosis in rats?
| Project/Area Number |
15K20080
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | University of Fukui |
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Principal Investigator |
SEKI Masaya 福井大学, 学術研究院医学系部門, 助教 (70572444)
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| Research Collaborator |
NAGASE Keiko 福井大学, 教務補佐員
ZHA Xinmin 福井大学, 教務補佐員
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 過活動膀胱 / 膀胱血流 / 低活動膀胱 |
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| Outline of Final Research Achievements |
Decreased blood flow due to atherosclerosis is considered to induce detrusor overactivity (DO) and later detrusor underactivity (DU). We examined the possibility that DO induces DU independently of atherosclerosis in a rat model of DO.
DO was induced by 4-week continuous intravesical infusion of carbachol (CCh). The CCh infusion induced frequent voiding and decreased voided volume. The strength of the contraction of bladder strip per tissue weight by high-potassium, CCh or electrical field stimulation was reduced in rats with CCh intravesical infusion compared to control rats. It is possible that DO induces DU independently of atherosclerosis.
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Report
(3 results)
Research Products
(6 results)
