| Project/Area Number |
15K20083
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
YAMAMOTO Tokunori 名古屋大学, 大学院医学系研究科, 准教授 (20182636)
FUNAHASHI Yasuhito 名古屋大学, 医学部附属病院, 助教 (70534824)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 低活動膀胱 / 脂肪幹細胞 / 再生治療 / 膀胱壁微小循環 / 膀胱再生 |
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| Outline of Final Research Achievements |
In this study, we injected adipose-derived stem cells for experimental animal model (rats) with underactive bladder and confirmed the differentiation to smooth muscle and bladder nerve of them. Additionally, the significant improvement of bladder functions, such as the decrease of residual urine and the improvement of voiding efficacy, and the significant contractile ability of bladder muscle by electrical stimulation were confirmed in the underactive baldder animal model.
In conclusion, adipose-derived stem cells for underactive bladder was effective in bladder functions and was found to be effective as a new therapy for underactive bladder in clinical practice.
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