Identification of new therapeutic items for drug resistant metastatic urothelial carcinoma

Research Project

Project/Area Number	15K20085
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Urology
Research Institution	Osaka University
Principal Investigator	Kawashima Atsunari 大阪大学, 医学系研究科, 寄附講座助教 (50746568)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	尿路上皮癌 / 膀胱癌
Outline of Final Research Achievements	Microarray analysis showed that several genes correlated with cell cycle and transcription were up-regulated in the metastatic urothelial carcinoma with poor prognosis. Moreover, immunological classification in the tumor micro environment was classified into two groups significantly correlated with prognosis and tumor grade. Especially, some genes ,which were reported to induce genome instability in urothelial carcinoma, was significantly correlated with prognosis and immunological classification. This result showed that new immunological agents such as anti PD-1 antibody was ideal agents in some metastatic urothelial carcinoma patients.