Identification of new therapeutic items for drug resistant metastatic urothelial carcinoma
Project/Area Number |
15K20085
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
|
Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 尿路上皮癌 / 膀胱癌 |
Outline of Final Research Achievements |
Microarray analysis showed that several genes correlated with cell cycle and transcription were up-regulated in the metastatic urothelial carcinoma with poor prognosis. Moreover, immunological classification in the tumor micro environment was classified into two groups significantly correlated with prognosis and tumor grade. Especially, some genes ,which were reported to induce genome instability in urothelial carcinoma, was significantly correlated with prognosis and immunological classification. This result showed that new immunological agents such as anti PD-1 antibody was ideal agents in some metastatic urothelial carcinoma patients.
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Report
(3 results)
Research Products
(1 results)