| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Our group has reported that the new organ preservation solution, SS-II solution, which contains 3 antioxidants: L-cysteine, glycine, ascorbic acid/ascorbic acid-2-phosphate magnesium, prolonged cold storage and protected the function and structure of myocardial from ischemia/reperfusion injury via inhibiting hypoxic and oxidative stress damage. In the present study, we evaluated the efficacy of SS-II solution in a rat kidney transplantation model. Syngeneic rat kidney transplantation was performed with grafts preserved in UW or SS-II solution for 24 hr. Recipient survival rate was significantly worse in SS-II group compared to UW group (UW vs. SS-II, 75% vs. 0%, respectively, at 60 days after kidney trasnplantation; p=0.0018). Thus, no protective effect of SS-II solution was observed in a rat kidney transplantation model. Further study is needed to adjust ingredients of our new preservation solution for kidney transplantation.
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