| Project/Area Number |
15K20088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
KAKUTA YOICHI 大阪大学, 医学系研究科, 助教 (40710116)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腎移植 / 拒絶反応 / バイオマーカー / 免疫プロファイル / モニタリング |
|---|
| Outline of Final Research Achievements |
We selected three genes from DNA array, CEACAM6, CEACAM8, and CCR3, to profile the immunosuppressive state after kidney transplantation, and established the original scoring. When we valiated this scoring in the other kidney transplant recipientgroup, both sensitivity and specificity was low. This is because few recipient suffered acute rejection, and variation of effects of immunosuppressive drug. We established rat model of acute T cell mediated rejection. Gene profiling was different between rat and human.
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