| Project/Area Number |
15K20093
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
huang peng 岡山大学, 医歯薬学総合研究科, 助教 (00610841)
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| Research Collaborator |
KUMON HIROMI 岡山大学, 医歯薬学総合研究科, 特命教授 (30144760)
NASU YASUTOMO 岡山大学, 医歯薬学総合研究科, 教授 (20237572)
WATANABE MASAMI 岡山大学, 大学病院, 教授 (70444677)
UEKI HIDEO 岡山大学, 医学部, 技術専門職員 (90537218)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 限増殖型アデノウイルスベクター / REIC/DKK-3 / 癌ワクチン / 抗癌免疫活性化 / 制限増殖型アデノウイルスベクター / 抗癌免疫制御 / 免疫活性 |
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| Outline of Final Research Achievements |
Reduced expression in immortalized cells (REIC)/Dickkopf 3 (Dkk-3) is a tumor suppressor gene that is downregulated in various cancers. We recently developed a novel specific replication-selective adenovirus Ad-REIC, to achieve more effective therapeutic outcomes and anti-cancer immune escape. In this study, we assessed the anti-tumor immunity effects of replication-selective adenovirus Ad-REIC, and the mechanism had been verify.
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