Research Project
Grant-in-Aid for Young Scientists (B)
We report that EPAC1 and EPAC2 expression levels were significantly lower in bladder cancer tissue than in normal bladder tissue. In addition, bladder cancer cell lines showed reduced EPAC1 mRNA expression. Furthermore, EPAC1 overexpression in bladder cancer cell lines induced morphologic changes and markedly suppressed cell migration without affecting cell viability. The overexpressed EPAC1 preferentially localized at cell-cell interfaces. In conclusion, reduced EPAC1 expression in bladder tumors and poor migration of EPAC1-overexpressing cells implicate EPAC1 as an inhibitor of bladder cancer cell migration.
All 2018 2017 2016 2015
All Journal Article (11 results) (of which Int'l Joint Research: 4 results, Peer Reviewed: 8 results, Open Access: 5 results, Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 4 results)
Biochemical and Biophysical Research Communications
Volume: 495 Issue: 1 Pages: 64-70
10.1016/j.bbrc.2017.10.142
Journal of Cellular Biochemistry
Volume: 119 Issue: 2 Pages: 1475-1487
10.1002/jcb.26308
Immunity
Volume: 46 Issue: 4 Pages: 675-689
10.1016/j.immuni.2017.03.019
Annals of oncology
Volume: 28(3) Issue: 3 Pages: 569-575
10.1093/annonc/mdw646
J Natl Cancer Inst.
Volume: 108 Issue: 7 Pages: djw005-djw005
10.1093/jnci/djw005
Pathobiology.
Volume: 83 Issue: 6 Pages: 277-286
10.1159/000445752
Cancer Science
Volume: ◯◯ Issue: 7 Pages: 1022-1028
10.1111/cas.12948
The Journal of Urology
Volume: 195
British Journal of Urology International
Volume: 117 (1) Issue: 1 Pages: 179-191
10.1111/bju.13180
Endocrine-related cancer
Volume: 22 Issue: 6 Pages: 889-900
10.1530/erc-15-0225
Cell Death & Differentiation
Volume: 22 Issue: 11 Pages: 1837-1845
10.1038/cdd.2015.38