The mechanism of the development of benign prostatic hyperplasia via extra cellarer matrix.
| Project/Area Number |
15K20102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
Takashi Hamakawa 名古屋市立大学, 大学院医学研究科, 研究員 (40595394)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 前立腺肥大症 / TSP-1 / 間質肥大 / IL-18 / 炎症 / 間質過形成 |
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| Outline of Final Research Achievements |
Previously, we reported that interleukin-18 (IL-18) may promote stromal hyperplasia in the prostate by inducing production of thrombospondin-1 (TSP-1) using BPH rat model. First, to clarify the role of TSP-1 in the development of BPH, we administered the IL-18-binding protein (IL-18BP), an inhibitor of IL-18, in the model rats. IL-18BP affected the dose-dependent decreases in TSP-1 mRNA expression levels. The collagen fibrils in the BPH tissues were likely decreased by IL-18BP.
Next study, we aimed to determine the expression levels of TSP-1 in human prostate tissue and assess the correlation of these expressions and clinical parameters. Also, we investigated the correlation between the ratio of prostate biopsy tissue component and IL-18 and TSP-1 expression. As a result, TSP-1 was positively correlated with prostate volume. A positive correlation was found between IL-18 expression and the ratio of glandular epithelium, and between TSP-1 expression and the area of smooth muscle.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] A pilot study of gemcitabine and paclitaxel as third-line chemotherapy in metastatic urothelial carcinoma.2017
Author(s)
Naiki Taku, Iida Keitaro, Kawai Noriyasu, Etani Toshiki, Ando Ryosuke, Nagai Takashi, Tanaka Yutaro, Hamamoto Shuzo, Hamakawa Takashi, Akita Hidetoshi, Sugiyama Yosuke, Yasui Takahiro
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Journal Title
The Japanese Association of Rural Medicine
Volume: 12
Pages: 105-111
NAID
Related Report
Peer Reviewed
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