| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Previously, we reported that interleukin-18 (IL-18) may promote stromal hyperplasia in the prostate by inducing production of thrombospondin-1 (TSP-1) using BPH rat model. First, to clarify the role of TSP-1 in the development of BPH, we administered the IL-18-binding protein (IL-18BP), an inhibitor of IL-18, in the model rats. IL-18BP affected the dose-dependent decreases in TSP-1 mRNA expression levels. The collagen fibrils in the BPH tissues were likely decreased by IL-18BP.
Next study, we aimed to determine the expression levels of TSP-1 in human prostate tissue and assess the correlation of these expressions and clinical parameters. Also, we investigated the correlation between the ratio of prostate biopsy tissue component and IL-18 and TSP-1 expression. As a result, TSP-1 was positively correlated with prostate volume. A positive correlation was found between IL-18 expression and the ratio of glandular epithelium, and between TSP-1 expression and the area of smooth muscle.
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