| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Male infertility is one of the most serious problem in our contry. We previously reported that spermatogonial stem cell (SSC) activity indicated future male fertility. However testicular histopathology and molecular mechanism against poor spermatogenesis were not elucidated. In this study, we performed human testicular biopsy and examined SSC funtion and Sertoli cells against risk disease of congenital male infertility. Our study showed that SSC's activity in cryptorchid testes which induced male infertility was already harmed in infant term. Moreover, in adult testes with past history of cryptorchidism might harm testicular function by SSCs activity loss, activation of apoptosis and disturbance of maturation of Sertoli cells.
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