| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Tumor microenvironment formation is one of the most critical event for cancer metastasis and malignancy. previously we generated the novel metastatic model of renal cancer using rat renal cell carcinoma cell line rRCCd5 which are established by us. In this study, we generated the highly lung metastatic clones of rRCCd5 via in vivo selection method, and underwent the phenotype screening of metastatic clones in vivo and in vitro and transcriptome analyses. These analyses revealed that over-expressions of protein X and Y in the highly metastatic clones might contribute to accelerate the lung metastasis ability via facilitating the cancer cluster formation by cancer cell adhesion dys-regulation.
Further study are needed for understanding the relationship between the protein X or Y and tumor microenvironment formation in the lung metastatic lesions of renal cancers.
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