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A new treatment strategy targeting to DNA repair pathway of castration resistant prostate cancer

Research Project

Project/Area Number 15K20108
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionKeio University

Principal Investigator

Kobayashi Hiroaki  慶應義塾大学, 医学部(信濃町), 助教 (10598428)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords去勢抵抗性前立腺癌 / ドセタキセル抵抗性 / PARP阻害剤 / DNA修復機構 / 合成致死 / アポトーシス / DNA修復経路
Outline of Final Research Achievements

In this study, we explored the efficacy of a PARP inhibitor for docetaxel resistant prostate cancer cell line: C4-2AT6. C4-2AT6 cells revealed combined administration of PARP inhibitor and docetaxel had a significant and synergistically high apoptosis inducing effect. In a castrated mice xenograft model, combined PARP inhibitor and docetaxel also showed high anti-tumor effect. These results suggested that inhibition of DNA repair pathway was able to overcome docetaxel resistance in human docetaxel resistant prostate cancer.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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