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New treatment strategy of refractory prostate cancer by targeting interdependent signaling pathways.

Research Project

Project/Area Number 15K20109
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionKeio University

Principal Investigator

Hongo Hiroshi  慶應義塾大学, 医学部(信濃町), 特任助教 (10626675)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords去勢抵抗性前立腺癌 / ドセタキセル耐性 / 相互依存的シグナル / アンドロゲン受容体 / 抗癌剤耐性 / 相互依存的シグナルネットワーク / 相互依存的シグナル機構
Outline of Final Research Achievements

We evaluated the therapeutic potential of targeting STAT5 signaling. We used two human prostate cancer cell lines: LNCaP, a androgen-dependent prostate cancer cell line; and C4-2AT6, a castration-resistant prostate cancer cell line. C4-2AT6 had docetaxel resistance. Western blotting showed higher expression of pAKT and pSTAT5 in C4-2AT6. We identified a novel stat5 inhibitor, ME001. ME001 had anti-tumor effect for C4-2AT6 in vitro and in vivo.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Headache Caused by Brain Metastases of Castration-resistant Prostate Cancer during Cabazitaxel Therapy2017

    • Author(s)
      Watanabe K, Kosaka T, Hongo H, Tamaki S, Oya M
    • Journal Title

      The Keio Journal of Medicine

      Volume: in printing

    • NAID

      130006279162

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Should We Try Antiandrogen Withdrawal in Castration-Resistant Prostate Cancer Patients? Insights From a Retrospective Study.2016

    • Author(s)
      Hongo H, Kosaka T, Mizuno R, Ezaki T, Matsumoto K, Morita S, Shinoda K, Shinojima T, Kikuchi E, Miyajima A, Oya M.
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: Epub ahead of print Issue: 6 Pages: e569-e573

    • DOI

      10.1016/j.clgc.2016.02.014

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Spontaneous Regression of Epstein-Barr Virus-Positive Primary Diffuse Large Cell B-Cell Lymphoma of the Urinary Bladder After the Cessation of Enzalutamide.2016

    • Author(s)
      Ogihara K, Kosaka T, Kikuchi E, Hongo H, Mikami S, Oya M.
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 14 Issue: 2 Pages: 215-8

    • DOI

      10.1016/j.clgc.2015.12.028

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Correlation between cabazitaxel resistance and epithelial-mesenchymal transition in metastatic castration-resistant prostate cancer2017

    • Author(s)
      Hiroshi Hongo, Takeo Kosaka, Yota Yazumizu, Yasumasa Miyazaki, Akira Miyajima, Mototsugu Oya
    • Organizer
      AUA annual meeting
    • Place of Presentation
      アメリカ、ボストン
    • Related Report
      2016 Annual Research Report
  • [Presentation] Therapeutic targeting of transcriptional repressor BCL-6 for enzalutamide resistant CRPC2017

    • Author(s)
      Hiroshi Hongo, Takeo Kosaka, Yota Yazumizu, Yasumasa Miyazaki, Akira Miyajima, Mototsugu Oya
    • Organizer
      AUA annual meeting
    • Place of Presentation
      アメリカ、ボストン
    • Related Report
      2016 Annual Research Report
  • [Presentation] Overcoming PI3K/mTOR inhibitor resistance by PIM1 inhibitor through regulation of tyrosine kinase expression2017

    • Author(s)
      Hiroshi Hongo, Takeo Kosaka, Yota Yazumizu, Yasumasa Miyazaki, Akira Miyajima, Mototsugu Oya
    • Organizer
      AUA annual meeting
    • Place of Presentation
      アメリカ、ボストン
    • Related Report
      2016 Annual Research Report
  • [Presentation] 転移性去勢抵抗性前立腺癌の遺伝子発現プロファイルに着目したリプログラミング候補薬剤のスクリーニング2016

    • Author(s)
      本郷周、小坂威雄、大家基嗣
    • Organizer
      第20回日本がん分子標的治療学会
    • Place of Presentation
      別府国際コンベンションセンター (大分県別府市)
    • Year and Date
      2016-05-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Bioinformatic analysis utilizing the androgenic suppressive effect identified promising candidate drugs for reprogramming docetaxel-resistant castration-resistant prostate cancer2016

    • Author(s)
      Hiroshi Hongo, Takeo Kosaka, Yota Yasumizu, Yasumasa Miyazaki, Eiji Kikuchi, Akira Miyajima, Mototsugu Oya
    • Organizer
      AUA annual meeting
    • Place of Presentation
      アメリカ合衆国、サンディエゴ
    • Year and Date
      2016-05-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2018-03-22  

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