The importance of regulation of the tumor microenvironment in cisplatin-resistant urothelial carcinoma
Project/Area Number |
15K20110
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Keio University |
Principal Investigator |
Niwa Naoya 慶應義塾大学, 医学部(信濃町), 助教 (40626743)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 尿路上皮癌 / 癌微小環境 / 上皮間葉転換 / シスプラチン / 抗癌剤耐性 / 抗癌剤 / TNFAIP2 / 抗がん剤耐性 / がん微小環境 |
Outline of Final Research Achievements |
Knockdown and overexpression of TNF-alpha induced protein 2 (TNFAIP2) in 5637 and its subline 5637PR with acquired platinum resistance resulted in suppression and overexpression of epithelial-mesenchymal transition related proteins, respectively. Immunohistochemical analysis in surgical specimens revealed that the expression of TNFAIP2 is significantly associated with oncologic outcome in patients with urothelial carcinoma. Moreover, overexpression and suppression of TNFAIP2 resulted in promotion and inhibition of cancer cells, respectively. These results suggested the importance of the regulation of the tumor microenvironment by targeting TNFAIP2 and its potential as a new therapeutic target.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Acquired platinum resistance involves epithelial-to-mesenchymal transition through ubiquitin ligase FBXO32 dysregulation2016
Author(s)
Tanaka N, Kosaka T, Miyazaki Y, Mikami S, Niwa N, Otsuka Y, Minamishima YA, Mizuno R, Kikuchi E, Miyajima A, Sabe H, Okada Y, Uhlen P, Suematsu M, Oya M
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Journal Title
JCI insight
Volume: 1
Issue: 18
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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