Dendritic cell involvment in endometriosis

• Project/Area Number: 15K20129
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokyo
• Principal Investigator: IZUMI Gentaro 東京大学, 医学部附属病院, 助教 (30714125)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 子宮内膜症 / 樹状細胞 / 子宮卵管造影 / 逆流説 / 腹腔 / 免疫療法 / CD206

Outline of Final Research Achievements

We analyse Myeloid dendritic cell type I(MDC1) in the peritoneal cavity. In endmetriosis patient, CD206 expression is significantly higher in endometriosis patients, though other type C lectin such as CLEC1, CLEC2, Dectin-1, Dectin-2 is not different.
Next, we blocked the expression of CD206 by D-mannan on dendritic cell. Endometriotic cell phagocytosis by dendritic cell was supressed by d-mannan. From our experiment, CD206 on dendritic cell in peritoneal cavity of endometriosis patients progress phagocytosis of endometriotic cells in retrograde menstruation, thus progress the endometriosis by secration of inflamattory cytokines.

Research Products

• [Journal Article] Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis. (2016)
  • Author(s): Izumi G, Koga K, Takamura M, Makabe T, Nagai M, Urata Y, Harada M, Hirata T, Hirota Y, Fujii T, Osuga Y.
  • Journal Title: Fertil Steril Volume: 107 Issue: 1 Pages: 167-173
  • DOI: 10.1016/j.fertnstert.2016.09.036
  • Peer Reviewed / Open Access / Int'l Joint Research