Breakthrough of the management of preterm labor -Usage of highly sensitive PCR system for detecting microorganisim in Amniotic fluid-
| Project/Area Number |
15K20133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
Yoneda Noriko 富山大学, 大学院医学薬学研究部(医学), 助教 (80377283)
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| Co-Investigator(Renkei-kenkyūsha) |
NIIMI Hideki 富山大学, 大学院医学薬学研究部(医学), 准教授 (50401865)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 早産 / 子宮内感染 / 迅速高感度病原微生物検出法 |
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| Outline of Final Research Achievements |
Intra-amniotic(IA) infection is one of the important risk factors for preterm birth.
1.We have established newly rapid and bacteria-free polymerase chain reaction (PCR) method. It was useful for detecting IA microorganisms. Polymicrobial infection with Mycoplasma/Ureaplasma and other bacteria induces severe IA inflammation associated with poor perinatal prognosis in preterm labor (PTL).
2.We examined the efficacy of the use of antibiotics in PTL with intact membranes, after evaluating intra-amniotic microbes by our PCR system. In the amniotic fluid (AF) microbe-negative PTL patients, antibiotic therapy significantly shortened the gestation period,whereas in the microbe-positive patients, appropriate antibiotic therapy (proper antibiotic selection against identified AF microbes) was significantly associated with an increase in gestation period . Appropriate antibiotic therapy in PTL with intact membranes prolonged the gestation period.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Polymicrobial Amniotic Fluid Infection with Mycoplasma/Ureaplasma and Other bacteria Induces Severe Intra-Amniotic Inflammation Associated with Poor Perinatal Prognosis in Preterm Labor.2016
Author(s)
Yoneda N, Yoneda S, Niimi H, Ueno T, Hayashi S, Ito M, Shiozaki A, Urushiyama D, Hata K, Suda W, Hattori M, Kigawa M, Kitajima I, Saito S.
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Journal Title
Am J Reprod Immunol
Volume: 75(2)
Pages: 112-25
Related Report
Peer Reviewed / Open Access
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[Journal Article] Antibiotic Therapy Increases the Risk of Preterm Birth in Preterm Labor without Intra-Amniotic Microbes, but may Prolong the Gestation Period in Preterm Labor with Microbes, Evaluated by Rapid and High-Sensitive PCR System2016
Author(s)
Yoneda S, Shiozaki A, Yoneda N, Ito M, Shima T, Fukuda K, Ueno T, Niimi H, Kitajima I, Kigawa M, Saito S
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Journal Title
American Journal of Reproductive Immunology
Volume: 75(4)
Issue: 4
Pages: 440-50
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 臨床化学2017
Author(s)
仁井見英樹
Total Pages
66
Publisher
日本臨床化学会
Related Report
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[Book] 周産期医学2016
Author(s)
米田徳子，仁井見英樹，米田 哲，齋藤 滋
Total Pages
119
Publisher
東京医学社
Related Report
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