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Elucidation of the functions of amino acid receptors in the early stage of the development of mammals, and examination of their application methods

Research Project

Project/Area Number 15K20134
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Toyama

Principal Investigator

Nishizono Hirofumi  富山大学, 研究推進機構 研究推進総合支援センター, 助教 (10502289)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords卵子品質 / 受精卵品質 / 卵子老化 / アミノ酸レセプター / ゲノム編集 / アミノ酸受容体
Outline of Final Research Achievements

Methods for preventing age-related quality deterioration of oocytes and embryos are very important research subjects in modern times when late marriage and late birth has progressed. In this study, the expression pattern of the glycine receptor found as a new candidate factor was clarified at each development stage. Furthermore, we succeeded in producing glycine receptor knockout mice using genomic editing with CRISPR / Cas 9. In the future, we plan to continue research using this knockout mouse.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Cleavage Speed and Blastomere Number in DBA/2J Compared with C57BL/6J Mouse Embryos2017

    • Author(s)
      Nishizono Hirofumi, Uno Kyosuke, Abe Hiroyuki
    • Journal Title

      Journal of the American Association for Laboratory Animal Science

      Volume: 56 Pages: 11-17

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 低品質胚と高品質胚のメタボローム解析による代謝中間体の解析と体外培養技術への応用2015

    • Author(s)
      西園啓文, 四ッ島賢二
    • Organizer
      日本繁殖生物学会
    • Place of Presentation
      宮崎
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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