Elucidation of the functions of amino acid receptors in the early stage of the development of mammals, and examination of their application methods
| Project/Area Number |
15K20134
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
Nishizono Hirofumi 富山大学, 研究推進機構 研究推進総合支援センター, 助教 (10502289)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 卵子品質 / 受精卵品質 / 卵子老化 / アミノ酸レセプター / ゲノム編集 / アミノ酸受容体 |
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| Outline of Final Research Achievements |
Methods for preventing age-related quality deterioration of oocytes and embryos are very important research subjects in modern times when late marriage and late birth has progressed. In this study, the expression pattern of the glycine receptor found as a new candidate factor was clarified at each development stage. Furthermore, we succeeded in producing glycine receptor knockout mice using genomic editing with CRISPR / Cas 9. In the future, we plan to continue research using this knockout mouse.
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Report
(3 results)
Research Products
(2 results)
