| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this research we examined the effect and mechanisms of cytotoxicity of plasma-activated medium (PAM) using ovarian cancer cells. Especially we focused on the chemo-resistant ovarian cancer cells. PAM treatment prolongs longevity in an ovarian cancer mouse model. Intraperitoneal PAM injection was applied in a mouse model of intraperitoneally injected with ES2 cells. The survival rates were better in the PAM treatment group than in the control group. Furthermore, using the IVIS imaging system, it was suggested that peritoneal metastatic was significantly inhibited by PAM, although the omentum showed no obvious recovery. PAM inhibited invasion and migration by repressing MMP-9 expression. In this research, PAM exerted the effect by inhibiting the phosphorylation of INK1/2 and p38.
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