Elucidation of cancer immunity escape mechanism in gynecological cancer
| Project/Area Number |
15K20149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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|---|
| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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|---|
| Keywords | 婦人科腫瘍 / がん免疫 / 婦人科がん / 免疫逃避 |
|---|
| Outline of Final Research Achievements |
Because of the deficiency of the tumor suppressor Menin, T cell antitumor activity decreased, which is thought to be caused by exhaustion in T cells. Therefore, we succeeded in constructing a model of tumor-bearing mice in which the antitumor activity of T cells was decreased due to Menin deficiency. From now on, we intend to develop a method for enhancing antitumor activity by suppressing fatigue mainly in this T cell exhaustion mouse model.
|
Report
(3 results)
Research Products
(2 results)
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[Journal Article] Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection2016
Author(s)
Yamada T, Kanoh M, Nabe S, Yasuoka T, Suzuki J, Matsumoto A, Kuwahara M, Maruyama S, Fujimoto T, Sakisuka R, Yasukawa M, and Yamashita M.
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Journal Title
Journal of Immunology
Volume: 197
Issue: 10
Pages: 4079-4089
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
