| Project/Area Number |
15K20149
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 婦人科腫瘍 / がん免疫 / 婦人科がん / 免疫逃避 |
|---|
| Outline of Final Research Achievements |
Because of the deficiency of the tumor suppressor Menin, T cell antitumor activity decreased, which is thought to be caused by exhaustion in T cells. Therefore, we succeeded in constructing a model of tumor-bearing mice in which the antitumor activity of T cells was decreased due to Menin deficiency. From now on, we intend to develop a method for enhancing antitumor activity by suppressing fatigue mainly in this T cell exhaustion mouse model.
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