Development of new treatment strategies targeting IMP3 in uterine carcinosarcoma
| Project/Area Number |
15K20161
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | 独立行政法人国立病院機構(東京医療センター臨床研究センター) (2016-2017)
Keio University (2015) |
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Principal Investigator |
Ueki Arisa 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 研究員 (60445319)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 子宮 / 癌肉腫 / IMP3 / エピジェネティクス |
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| Outline of Final Research Achievements |
IMP3 (Igf2 mRNA- binding protein 3) is regarded as a novel oncofetal protein expressed especially during early stage of embryogenesis, but also re-expressed in many malignant tissues. Here we found significant correlation between IMP3 expression and overall survival in human uterine carcinosarcoma (CS).
Histone modification status was also correlated to the IMP3 expression, and considered as an independent prognostic factor in CS. These findings suggested that IMP3 expression might confer epigenetic histone modification. To clarify further mechanical regulation on IMP3 leads to the establishment of new prognostic factors as well as solid therapeutic procedures in CS.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] 一般病院における家族性腫瘍相談外来とハイリスク外来の開設―一般病院に求められる家族性腫瘍診療の意義についての考察―.2017
Author(s)
植木有紗, 中田さくら, 安齋純子, 麻薙美香, 嶋田恭輔, 久保内光一, 三須久美子, 平沢晃, 阪埜浩司, 菅野康吉, 小崎健次郎, 青木大輔.
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Journal Title
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] 卵巣癌2015
Author(s)
植木有紗、増田健太、平沢晃、中田さくら、青木大輔
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Journal Title
日本臨牀増刊号 家族性腫瘍学ー家族性腫瘍の最新研究動向ー
Volume: 73(6)
Pages: 462-466
Related Report
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[Journal Article] Synergistic antiproliferative effect of imatinib and adriamycin in platelet-derived growth factor receptor-expressing osteosarcoma cells.2015
Author(s)
Yamaguchi SI, Ueki A, Sugihara E, Onishi N, Yaguchi T, Kawakami Y, Horiuchi K, Morioka H, Matsumoto M, Nakamura M, Muto A, Toyama Y, Saya H, Shimizu T.
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Journal Title
Cancer Sci.
Volume: 106
Issue: 7
Pages: 875-882
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.2015
Author(s)
Masuda K, Chiyoda T, Sugiyama N, Segura-Cabrera A, Kabe Y, Ueki A, Banno K, Suematsu M, Aoki D, Ishihama Y, Saya H, Kuninaka S
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Journal Title
PLoS One
Volume: 10
Issue: 2
Pages: 1-22
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinicopathologic analysis with immunohistochemistry for DNA mismatch repair protein expression in synchronous primary endometrial and ovarian cancers.2015
Author(s)
Kobayashi Y, Nakamura K, Nomura H, Banno K, Irie H, Adachi M, Iida M, Umene K, Nogami Y, Masuda K, Kisu I, Ueki A, Yamagami W, Kataoka F, Hirasawa A, Tominaga E, Susumu N, Aoki D.
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Journal Title
International Journal of Gynecological Cancer
Volume: 25(3)
Issue: 3
Pages: 440-446
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Risk-reducing surgery in hereditary gynecological cancer: Clinical applications in Lynch syndrome and hereditary breast and ovarian cancer.2015
Author(s)
Adachi M, Banno K, Yanokura M, Iida M, Nakamura K, Nogami Y, Umene K, Masuda K, Kisu I, Ueki A, Hirasawa A, Tominaga E, Aoki D.
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Journal Title
Molecular and Clinical Oncology
Volume: 3(2)
Issue: 2
Pages: 267-273
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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