Analysis of cell-free mRNA in first trimester plasma from pregnant women who would develop fetal growth restriction or hepertensive disorders of pregnancy

Research Project

Project/Area Number	15K20162
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Obstetrics and gynecology
Research Institution	Showa University
Principal Investigator	Takenaka Shin 昭和大学, 医学部, 助教 (60515211)
Research Collaborator	KOIDE Keiko (90384437) SEIKIZAWA Akihiko (10245839)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	胎児発育不全 / 胎盤機能 / 母体血中cell-free RNA / 妊娠高血圧症候群
Outline of Final Research Achievements	At 8-11 weeks of gestation, cell-free HOXC4 mRNA level in plasma of pregnant women who would develop fetal growth restriction later was statistically higher than normal pregnant women. It was suggested that HOXC4 was one of the key genes in understanding pathogenesis of fetal growth restriction.