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CD98 is the marker of cancer stem cell and radioresistance

Research Project

Project/Area Number 15K20177
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionAkita University

Principal Investigator

Kawasaki Yohei  秋田大学, 医学部, 助教 (00644072)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsCD98hc / 癌幹細胞 / 放射線耐性 / 頭頸部扁平上皮癌 / 頭頚部扁平上皮癌 / 放射線感受性 / CD98 / CD326
Outline of Final Research Achievements

In head and neck cancer, failure in radiotherapy causes subsequent life prognosis failure. 60 Gy radiation was applied to five head and neck squamous cell carcinoma cell lines HO-1-u-1, Sa 3, HSC 2, HSC 3, HSC 4. Overexpression of CD98hc was confirmed in all cells, and Colony forming ability and migration ability were enhanced. When only CD98hc positive cells were extracted, it was found that Colony forming ability, invasion ability, and adhesion ability were enhanced as compared with the negative cells. Furthermore, it had high tumorigenicity in animal experiments. The amino acid transporter CD98hc will be a target for cancer therapy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results) Funded Workshop (1 results)

  • [Journal Article] Increased Expression of CD44v9, Cancer Stem Cell Marker, in Head and Neck Squamous Carcinoma cells after Irradiation2017

    • Author(s)
      Yohei Kawasaki, Yasufumi Omori, Takechiyo Yamada
    • Journal Title

      International Journal of Cancer and Oncology

      Volume: Volume4:Issue2 Issue: 3 Pages: 225-230

    • DOI

      10.15436/2377-0902.17.1628

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] CD98hcは放射線感受性のマーカーであり、癌幹細胞の性質をもつ2018

    • Author(s)
      川嵜洋平、大森泰文
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌におけるCD98陽性細胞は放射線療法抵抗性のマーカーである2018

    • Author(s)
      川嵜洋平、大森泰文、山田竹千代
    • Organizer
      第28回日本サイトメトリー学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The expression of CD98hc might be a marker of radiation resistance in HNSCC2017

    • Author(s)
      Yohei Kawasaki
    • Organizer
      AACR
    • Place of Presentation
      Washington D.C
    • Year and Date
      2017-04-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] CD98は癌幹細胞・放射線感受性のマーカーである2017

    • Author(s)
      川嵜洋平、大森泰文、山田武千代
    • Organizer
      第27回日本サイトメトリー学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌は放射線照射によってCD98hc+/CD44v9+の細胞集団が増加する2017

    • Author(s)
      川嵜洋平、大森泰文
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The expression of CD98hc might be a marker of radiation resistance in HNSCC2017

    • Author(s)
      Yohei Kawasaki, Yasufumi Omori
    • Organizer
      AACR Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 頭頸部扁平上皮癌においてCD98は放射線耐性のマーカーとなりうる2016

    • Author(s)
      川嵜洋平
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頭頚部扁平上皮癌においてCD98は放射線耐性のマーカーとなりうる2016

    • Author(s)
      川嵜洋平
    • Organizer
      第75回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2015 Research-status Report
  • [Funded Workshop] 日本癌学会2016

    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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