Determination of the invasion mechanism of adenoid cystic carcinoma using patient-derived xenograft model
| Project/Area Number |
15K20186
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ando Mizuo 東京大学, 医学部附属病院, 講師 (60511467)
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| Research Collaborator |
KAWAZU Masahito
MATSUMOTO Yu
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腺様嚢胞癌 / 動物モデル / 遠隔転移 / がんゲノム / 疾患動物モデル / 神経浸潤 / 網羅的ゲノム解析 |
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| Outline of Final Research Achievements |
We generated three PDX (patient-derived xenograft) models from patients with adenoid cystic carcinoma. One model has distant pulmonary metastasis which is of substantial importance on deciphering the mechanisms of invasion in adenoid cystic carcinoma. By comparing genome-wide data of patient’s peripheral blood, primary tumor, and PDXs (subcutaneous tumor and lung metastasis), we detected characteristic genomic alterations of metastatic tumor cells. To reveal factors promoting metastasis, we examined intravenous administration and invasive surgical procedure to the PDX model but failed to identify any possible factors that might affect metastatic potential. We have also developed the international research project collaborated with University of California, San Diego.
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Report
(4 results)
Research Products
(7 results)
