| Project/Area Number |
15K20192
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIZAKI Tomokazu 金沢大学, 医学系, 教授 (70262582)
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| Research Collaborator |
WAKISAKA Naohiro 金沢大学, 医学系, 准教授 (70377414)
KONDO Satoru 金沢大学, 附属病院, 講師 (70436822)
ENDO Kazuhira 金沢大学, 附属病院, 助教 (30547154)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 中咽頭癌 / 喉頭乳頭腫 / APOBEC family / APOBEC / HPV / human papilloma virus / ヒトパピローマウイルス |
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| Outline of Final Research Achievements |
We found that the expression of the apolipoprotein B mRNA-editing catalytic polypeptide (APOBEC) 3A, C, F, and H was higher in HPV positive oropharyngeal cancer (OPC) tissues than HPV negative OPC tissues. However, only the A3F was expressed in HPV positive laryngeal papilloma. We failed in conducting the transduction of the HPV gene into oropharyngeal cancer cell line because of low transduction efficiency.
We identified APOBEC family highly expressed in oropharyngeal cancer, It was suggested that laryngeal papilloma avoided the host immune response.
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