| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Eosinophilic chronic sinusitis shows increased innate lymphoid cells in the tissue. Although, little is known about the role of innate lymphoid cells. In this research, we examined the expression and the role of innate lymphoid cells in eosinophilic sinusitis. We use nasal polyp cell which were collected at the sinus surely. Innate lympgoid cells are known for the strong cytokine producing ability. Innate lympgoid cells were isolated from nasal polyp cells and stimulated with staphylococcal enterotoxin B.
Innate lympgoid cells showed enhanced production of type 2 cytokines which exacerbate eosinophilic inflammation. On the other hand, production of type 1 cytokines seem to be inhibited.
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