Expression of innate lympgoid cell and its response to microbial components in eosinophilic upper airway inflammation
| Project/Area Number |
15K20210
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 自然リンパ球 / 好酸球性副鼻腔炎 / IL-5 / IL-13 / 鼻茸 / CD127 / Lineage / IFN-γ |
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| Outline of Final Research Achievements |
Eosinophilic chronic sinusitis shows increased innate lymphoid cells in the tissue. Although, little is known about the role of innate lymphoid cells. In this research, we examined the expression and the role of innate lymphoid cells in eosinophilic sinusitis. We use nasal polyp cell which were collected at the sinus surely. Innate lympgoid cells are known for the strong cytokine producing ability. Innate lympgoid cells were isolated from nasal polyp cells and stimulated with staphylococcal enterotoxin B.
Innate lympgoid cells showed enhanced production of type 2 cytokines which exacerbate eosinophilic inflammation. On the other hand, production of type 1 cytokines seem to be inhibited.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] IL-22/IL-22R1 signaling regulates the pathophysiology of chronic rhinosinusitis with nasal polyps via alteration of MUC1 expression.2016
Author(s)
Noyama Y, Okano M, Fujiwara T, Kariya S, Higaki T, Haruna T, Makihara S, Kanai K, Koyama T, Taniguchi M, Ishitoya J, Kanda A, Kobayashi Y, Asako M, Tomoda K, Nishizaki K.
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Journal Title
Allergology International
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps2016
Author(s)
Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, Noyama Y, Koyama T, Omichi R, Orita Y, Miki K, Kanai K, Nishizaki K.
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Journal Title
Allergology International
Volume: 65
Issue: 1
Pages: 96-102
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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