New oral immunotherapy with Cry j 1-galactomannan conjugate for Japanese cedar pollinosis: a randomized controlled trial.
| Project/Area Number |
15K20211
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アレルギー性鼻炎 / スギ花粉症 / 経口免疫療法 / 花粉症 / スギ抗原-ガラクトマンナン複合体 |
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| Outline of Final Research Achievements |
The prevalence of Japanese cedar pollinosis (JCP) has been increasing, and is currently around 30%. JCP is now called a part of Japanese national disease, but until now there has been no treatment to improve the allergy constitution in a short term regimen. Therefore, we developed a new oral immunotherapy to take antigen-galactomannan conjugate capsules using intestinal immunity. In addition, the treatment period is very short for about 2 months before and after the pollen is scattered. In this RCT, OIT with antigen-galactomannan conjugate was safe and approved to reduce anti-allergic medicine by about 60% compared to standard treatment.In the near future, there is a possibility that it will lead to a new immunotherapy to improve the allergy constitution.
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Report
(4 results)
Research Products
(5 results)
