| Project/Area Number |
15K20212
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 放射線性唾液腺障害 / rapamycin / 放射線正唾液腺障害 / 唾液腺 / 放射線 |
|---|
| Outline of Final Research Achievements |
Radiation therapy is effective for head and neck squamous cell carcinoma and useful for organ preservation, however radiation induces permanent xerostomia due to salivary gland damage. It is reported that ramapycin, mTOR inhibitor, removes intracellular reactive oxygen species(ROS) in human oral keratinocytes and prevents senescence. This study shows rapamycin inhibits intracellular ROS production in normal salivary gland cell. This result indicates rapamycin inhibits ROS in irradiated salivary gland cells, too. Moreover, rapamycin might protect radiation induced salivary gland disorder.
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