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The relationship between follicular helper T cells and pathogenesis of tonsillar hypertrophy in patients with child OSAS

Research Project

Project/Area Number 15K20213
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionSapporo Medical University

Principal Investigator

Tsubomatsu Chieko  札幌医科大学, 医学部, 助教 (40468096)

Co-Investigator(Renkei-kenkyūsha) HIMI Tetsuo  札幌医科大学, 医学部, 教授 (90181114)
ICHIMIYA Shingo  札幌医科大学, 医学部, 教授 (30305221)
KAMEKURA Ryuta  札幌医科大学, 医学部, 講師 (70404697)
NAGAYA Tomonori  札幌医科大学, 医学部, 助教 (60517902)
YAMASHITA Keiji  札幌医科大学, 医学部, 研究員 (50583580)
SHINTANI Tomoko  とも耳鼻咽喉科, 院長 (10244352)
Research Collaborator Ito Fumie  
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords扁桃肥大 / 睡眠時無呼吸症候群 / アデノイド肥大 / 機能性リンパ球 / 濾胞ヘルパーT細胞 / 脂質メディエーター / 機能性Tリンパ球 / 濾胞ヘルパーT細胞 / 粘膜免疫 / 粘膜関連リンパ組織 / 加齢変化 / .扁桃 / 粘膜関連リンパ装置 / リンパ濾胞
Outline of Final Research Achievements

Obstructive sleep apnea syndrome (OSAS) in childhood is caused by adeno-tonsillar hypertrophy, and adeno-tonsillectomy is commonly performed as a treatment.Histologically, tonsillar hypertrophy is characterized by prominent germinal centers (GCs). Antigen specific humoral immune responses are established by the active interactions of B and Tfh cells (follicular helper T cells) in GCs. Therefore, we focused on the potential of these cells to induce lymphoid hyperplasia promoted in OSAS pathogenesis. The results revealed that the tonsils of OSAS were considerably different from those of RT tonsils in terms of Tfh cells. Moreover, lipoxin A4 and leukotriene B4 have the capacity to differentiate naive CD4+ T cells into Tfh cells. The results suggest that such lipid mediators have a potential role in the development of lymphoid follicles through the regulation of Tfh cell differentiation and regulation of these mediators should be considered as a candidate of conservative treatment.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome in Children.2016

    • Author(s)
      Tsubomatsu C, Shintani T, Abe A, Yajima R, Takahashi N, Ito F, Takano K, Himi T.
    • Journal Title

      Adv Otorhinolaryngol.

      Volume: 77 Pages: 105-111

    • DOI

      10.1159/000441886

    • ISBN
      9783318056501, 9783318056518
    • Related Report
      2016 Annual Research Report
  • [Journal Article] Influence of Age on Caloric Response.2016

    • Author(s)
      Jitsukawa S, Takano K, Ito F, Tsubomatsu C, Himi T.
    • Journal Title

      Adv Otorhinolaryngol.

      Volume: 77 Pages: 17-22

    • DOI

      10.1159/000441864

    • ISBN
      9783318056501, 9783318056518
    • Related Report
      2016 Annual Research Report
  • [Journal Article] Cochlear Implantation in Children with Cochlear Malformation.2016

    • Author(s)
      Saikawa E, Takano K, Ogasawara N, Tsubomatsu C, Takahashi N, Shirasaki H, Himi T.
    • Journal Title

      Adv Otorhinolaryngol.

      Volume: 77 Pages: 7-11

    • DOI

      10.1159/000441859

    • ISBN
      9783318056501, 9783318056518
    • Related Report
      2016 Annual Research Report
  • [Journal Article] 小児OSASにおけるIntegrated PSG systemの検討2016

    • Author(s)
      坪松 ちえ子, 新谷 朋子, 氷見 徹夫
    • Journal Title

      口腔・咽頭科

      Volume: 29 Pages: 213-218

    • NAID

      130005265162

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 扁桃・アデノイドの基礎知識と手術治療に関連する問題点2016

    • Author(s)
      氷見 徹夫, 高野 賢一, 亀倉 隆太, 山下 恵司, 小笠原 徳子, 坪松 ちえ子
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 119 Pages: 701-712

    • NAID

      130005156695

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome in Children2016

    • Author(s)
      Tsubomatsu, C.; Abe, A.; Yajima, R.; Takahashi, N.; Ito, F.; Takano, K.; Himi, T.
    • Journal Title

      Adv Otorhinolaryngol

      Volume: 77 Pages: 105-111

    • DOI

      10.1159/000441858

    • ISBN
      9783318056501, 9783318056518
    • Related Report
      2015 Research-status Report
  • [Presentation] IgG4関連涙腺唾液腺炎における活性化濾胞ヘルパーT細胞のIgG4産生への関与2016

    • Author(s)
      亀倉 隆太, 高野 賢一, 長屋 朋典, 實川 純人, 伊藤 史恵, 坪松 ちえ子, 一宮 慎吾, 氷見 徹夫
    • Organizer
      第29回日本口腔咽頭科学会
    • Place of Presentation
      松江テルサ(島根県松江市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] IgG4関連疾患における線維化関連因子の検討2016

    • Author(s)
      高野 賢一, 矢島 諒人, 亀倉 隆太, 坪松 ちえ子, 氷見 徹夫
    • Organizer
      第29回日本口腔咽頭科学会
    • Place of Presentation
      松江テルサ(島根県松江市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小児閉塞性睡眠時無呼吸におけるアデノイド・口蓋扁桃所見と重症度の検討2016

    • Author(s)
      坪松 ちえ子, 高野 賢一, 新谷 朋子, 氷見 徹夫
    • Organizer
      第29回日本口腔咽頭科学会
    • Place of Presentation
      松江テルサ(島根県松江市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小児OSAにおけるIntegrated PSG Systemの検討2016

    • Author(s)
      坪松 ちえ子, 新谷 朋子, 氷見 徹夫
    • Organizer
      第41回日本睡眠学会定期学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] ダウン症と高度肥満を伴った重度睡眠時無呼吸症例の治療経験2016

    • Author(s)
      坪松 ちえ子, 新谷 朋子, 氷見 徹夫
    • Organizer
      第11回日本小児耳鼻咽喉科学会
    • Place of Presentation
      ホテルクレメント徳島(徳島県徳島市)
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
  • [Presentation] 小児OSASにおけるIntegrated PSG Systemの検討2015

    • Author(s)
      坪松ちえ子
    • Organizer
      第28回日本口腔咽頭科学会
    • Place of Presentation
      ホテル阪神 大阪市福島区
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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