Prognostic value of Metabolic Tumor Volume (MTV) in patients with head and neck cancer treated by radiation-based therapy

• Project/Area Number: 15K20218
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Yokohama City University
• Principal Investigator: YABUKI Kenichiro 横浜市立大学, 附属病院, 助教 (50722774)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: Metabolic Tumor Volume / 頭頸部癌 / FDG-PET

Outline of Final Research Achievements

Background: The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with head and neck cancer treated by radiation-based therapy. Methods: This retrospective study included 118 patients with laryngeal carcinoma and 100 patients with piriform sinus carcinomas, who had received treatment by radiation-based therapy. The MTV values were obtained from pretreatment positron emission tomography. The association between clinical factors, including the MTV, and survival was analyzed. Results: Kaplan-Meier estimates revealed the 5-year disease-free survival (DFS) rates were significantly poorer for patients with a high MTV compared to those with a low MTV. In the multivariate analysis, MTV was found to be independent prognostic factors for DFS. Conclusions: The pretreatment MTV is a prognostic factor for DFS in laryngeal carcinoma patients and piriform sinus carcinoma patients treated by radiation-based therapy.

Research Products

• [Journal Article] Surgery-based versus radiation-based treatment strategy for a high metabolic volume laryngeal cancer. (2017)
  • Author(s): abuki K, Sano D, Shiono O, Arai Y, Chiba Y, Tanabe T, Nishimura G, Takahashi M, Taguchi T, Kaneta T, Hata M, Oridate N
  • Journal Title: Laryngoscope Volume: 127 Issue: 4 Pages: 862-867
  • DOI: 10.1002/lary.26233
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prognostic significance of metabolic tumor volume in patients with piriform sinus carcinoma treated by radiotherapy with or without concurrent chemotherapy. (2016)
  • Author(s): Yabuki K, Sano D, Shiono O, Arai Y, Takahashi H, Chiba Y, Tanabe T, Nishimura G, Takahashi M, Taguchi T, Kaneta T, Hata M, Oridate N
  • Journal Title: Head Neck Volume: 38 Issue: 11 Pages: 1666-1671
  • DOI: 10.1002/hed.24488
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Imaging strategy for response evaluation to chemoradiotherapy of the nodal disease in patients with head and neck squamous cell carcinoma. (2016)
  • Author(s): Nishimura G, Yabuki K, Hata M, Komatsu M, Taguchi T, Takahashi M, Shiono O, Sano D, Arai Y, Takahashi H, Chiba Y, Oridate N
  • Journal Title: Int J Clin Oncol Volume: 21 Issue: 4 Pages: 658-67
  • DOI: 10.1007/s10147-015-0936-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reduction surgery using a combination of a stereolithographic model and navigation system for ossifying fibroma with secondary central giant cell granuloma. (2016)
  • Author(s): Arai Y, Chiba Y, Umeda S, Ohara Y, Iwai T, Komatsu M, Yabuki K, Sano D, Oridate N
  • Journal Title: Auris Nasus Larynx Volume: 43 Issue: 2 Pages: 207-211
  • DOI: 10.1016/j.anl.2015.08.003
  • NAID: 130005250413
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Treatment results and prognostic factors for advanced squamous cell carcinoma of the head and neck treated with salvage surgery after concurrent chemoradiotherapy. (2016)
  • Author(s): Taguchi T, Nishimura G, Takahashi M, Shiono O, Komatsu M, Sano D, Yabuki KI, Arai Y, Yamashita Y, Yamamoto K, Sakuma Y, Oridate N
  • Journal Title: Int J Clin Oncol Volume: 21 Issue: 5 Pages: 869-874
  • DOI: 10.1007/s10147-016-0964-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 喉頭癌におけるMetabolic Tumor Volumeと予後との相関 (2016)
  • Author(s): 矢吹健一郎
  • Journal Title: 喉頭 Volume: 29 Pages: 57-60
  • NAID: 130006792078
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 口蓋扁桃摘出術の術後出血に対するビデオ喉頭鏡システム下での血管クリップの使用経験 (2016)
  • Author(s): 矢吹健一郎，磯野泰大，折舘伸彦
  • Journal Title: 口咽科 Volume: 29 Pages: 175-178
  • NAID: 130005265210
  • Peer Reviewed
• [Journal Article] Predictive and Prognostic value of Metabolic Tumor Volume (MTV) in patients with laryngeal carcinoma treated by Radiotherapy (RT) / Concurrent Chemoradiotherapy (CCRT). (2016)
  • Author(s): Yabuki K, Shiono O, Komatsu M, Sano D, Nishimura G, Takahashi M, Taguchi T, Inoue T, Oridate N.
  • Journal Title: PLoS One Volume: 10 Issue: 3 Pages: 263-263
  • DOI: 10.1016/j.anl.2015.02.014
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A fibrin seal closure technique for prolonged postoperative pharyngocutaneous fistula (2015)
  • Author(s): 矢吹 健一郎, 佐野 大佑, 西村 剛志, 百束 紘, 荒井 康裕, 小松 正規, 田口 享秀, 折舘 伸彦.
  • Journal Title: JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY Volume: 25 Issue: 1 Pages: 99-102
  • DOI: 10.5106/jjshns.25.99
  • NAID: 130005091170
  • ISSN: 1349-581X, 1884-474X
  • Peer Reviewed
• [Journal Article] Concurrent Chemoradiotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) in Patients with Nasopharyngeal Carcinoma. (2015)
  • Author(s): Komatsu M, Arai Y, Yabuki K, Sano D, Shiono O, Sakuma Y, Nishimura G, Takahashi M, Taguchi T, Oridate N.
  • Journal Title: Anticancer Res. Volume: 35 Pages: 6861-6867
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 喉頭癌におけるMetabolic Tumor Volumeと予後との相関 (2016)
  • Author(s): 矢吹健一郎
  • Organizer: 第28回 日本喉頭科学会総会・学術総会(大阪)，2016, 3 シンポジウム2「局所進行喉頭・下咽頭癌 喉頭温存に向けたcutting edge-」
  • Place of Presentation: コングレコンベンションセンター(大阪府)
  • Year and Date: 2016-03-03
  • Invited
• [Presentation] Prognostic value of MTV in patients with laryngeal carcinoma treated by RT / CCRT (2015)
  • Author(s): Kenichiro Yabuki, Osamu Shiono, Masanori Komatsu, Yasuhiro Arai, Daisuke Sano, Goshi Nishimura, Takahide Taguchi and Nobuhiko Oridate.
  • Organizer: 第39回日本頭頸部癌学会 第4回アジア頭頸部癌学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] 下咽頭(梨状陥凹)癌におけるMetabolic Tumor Volumeと予後との相関 (2015)
  • Author(s): 矢吹健一郎, 荒井康裕, 佐野大佑, 小松正規, 塩野理, 高橋優宏, 西村剛志, 田口享秀, 折舘伸彦.
  • Organizer: 第116回日本耳鼻咽喉科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2015-05-20