| Project/Area Number |
15K20218
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | Metabolic Tumor Volume / 頭頸部癌 / FDG-PET |
|---|
| Outline of Final Research Achievements |
Background: The purpose of this study was to elucidate the prognostic significance of the pretreatment metabolic tumor volume (MTV) in patients with head and neck cancer treated by radiation-based therapy. Methods: This retrospective study included 118 patients with laryngeal carcinoma and 100 patients with piriform sinus carcinomas, who had received treatment by radiation-based therapy. The MTV values were obtained from pretreatment positron emission tomography. The association between clinical factors, including the MTV, and survival was analyzed. Results: Kaplan-Meier estimates revealed the 5-year disease-free survival (DFS) rates were significantly poorer for patients with a high MTV compared to those with a low MTV. In the multivariate analysis, MTV was found to be independent prognostic factors for DFS. Conclusions: The pretreatment MTV is a prognostic factor for DFS in laryngeal carcinoma patients and piriform sinus carcinoma patients treated by radiation-based therapy.
|
