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Neural mechanisms of coordination between swallowing and respiration due to the effect of stimulation to the larynx

Research Project

Project/Area Number 15K20220
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Sugiyama Yoichiro  京都府立医科大学, 医学(系)研究科(研究院), 助教 (50629566)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords喉頭 / 嚥下 / 電気生理学 / 喉頭科学
Outline of Final Research Achievements

We first examined the contribution of the respiratory neurons in the parafacial respiratory group in the medulla, which can control the expiratory phase of breathing, to the swallowing regulation, in order to assess whether the respiratory neuronal networks could participate in the swallowing central pattern generation. In addition, we tested for effects of electrical stimulation of the neck to the swallowing reflexibility as well as respiratory rhythmogenesis. Consequently, our data suggested that the neurons of the parafacial respiratory group may contribute to the regulation of swallowing and that the surface electrical stimulation of the neck could modulate the swallowing central pattern generator in the medulla resulting in improvement of the laryngeal sensation to elicit swallowing.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] 延髄の嚥下中枢とcentral pattern generator2017

    • Author(s)
      杉山庸一郎
    • Journal Title

      摂食嚥下障害リハビリテーションABC

      Volume: 212 Pages: 33-39

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse2016

    • Author(s)
      Mukudai et al.
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 49 Issue: 1 Pages: 37-46

    • DOI

      10.1267/ahc.15037

    • NAID

      130005128328

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of the retrotrapezoid nucleus/parafacial respiratory group in coughing and swallowing in guinea pigs.2015

    • Author(s)
      Sugiyama Y, Shiba K, Mukudai S, Umezaki T, Sakaguchi H, Hisa Y
    • Journal Title

      J Neurophysiol

      Volume: 114 Issue: 3 Pages: 1792-1805

    • DOI

      10.1152/jn.00332.2015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Differential responses to steroid hormones in fibroblasts from the vocal fold, trachea, and esophagus.2015

    • Author(s)
      Mukudai S, Matsuda K I, Nishio T, Sugiyama Y, Bando H, Hirota R, Sakaguchi H, Hisa Y, Kawata M
    • Journal Title

      Endocrinology

      Volume: 156 Issue: 3 Pages: 1000-1009

    • DOI

      10.1210/en.2014-1605

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 発声・嚥下の脳幹における中枢処理機構2018

    • Author(s)
      杉山庸一郎
    • Organizer
      第30回日本喉頭科学会総会・学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 嚥下セントラルパターンジェネレーターの機能に迫る多角的アプローチ2018

    • Author(s)
      杉山庸一郎
    • Organizer
      第41回日本嚥下医学会総会ならびに学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 干渉波電気刺激による嚥下惹起性の改善に関する検討2017

    • Author(s)
      杉山庸一郎、梅崎俊郎、布施慎也、椋代茂之、板東秀樹、平野滋
    • Organizer
      日本嚥下医学会
    • Place of Presentation
      東京
    • Year and Date
      2017-02-24
    • Related Report
      2016 Research-status Report
  • [Presentation] モルモット嚥下関連ニューロンにおける干渉波電気刺激による応答2017

    • Author(s)
      杉山庸一郎
    • Organizer
      第69回 日本気管食道科学会総会ならびに学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of Chemical Stimulation of the Parabrachial Nucleus on Vocal Motor Regulation in Guinea Pigs2017

    • Author(s)
      Yoichiro Sugiyama
    • Organizer
      Combined otolaryngology spring meetings
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 嚥下を制御している脳のしくみ~脳幹の神経ネットワークを中心に~2016

    • Author(s)
      杉山庸一郎
    • Organizer
      東北摂食嚥下リハビリテーション研究会
    • Place of Presentation
      仙台
    • Year and Date
      2016-10-16
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] モルモット傍顔面神経核呼吸ニューロン群における咳、嚥下制御機構2016

    • Author(s)
      杉山庸一郎、布施慎也、椋代茂之、西尾健志、板東秀樹、柴啓介、梅崎俊郎、坂口博文、久育男
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 傍顔面神経核呼吸ニューロン群における咳、嚥下時活動2016

    • Author(s)
      杉山庸一郎
    • Organizer
      第28回日本喉頭科学会
    • Place of Presentation
      大阪
    • Year and Date
      2016-03-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳幹神経ネットワークによる嚥下制御機構2016

    • Author(s)
      杉山庸一郎
    • Organizer
      第39回日本嚥下医学会
    • Place of Presentation
      大阪
    • Year and Date
      2016-02-13
    • Related Report
      2015 Research-status Report
  • [Presentation] The contribution of the retrotrapezoid nucleus/parafacial respiratory group to the regulation of coughing and swallowing in guinea pigs.2015

    • Author(s)
      Sugiyama Yoichiro
    • Organizer
      13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery.
    • Place of Presentation
      Tokyo
    • Year and Date
      2015-12-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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